To understand the physically addictive nature of cocaine, it is essential to understand its meaning. People often get confused between psychological and physical addiction. In fact, physical addiction means the dependence of body on a drug to act normal or addicted.
In the medical field, addiction is defined as changes to the reward system of the human brain. It may lead to ingestion of intoxicating matters or neurotic pursuit.
If a person struggles with addiction, the possibilities of developing a bodily dependence on this drug are high in addition to psychological changes. Physical dependence involves the variations to a way to the release of neurotransmitters by the human brain. A drug may be responsible to release more dopamine, serotonin and other blends of neurotransmitters. In this situation, the brain continues the release procedure and require more drug to reach to an equilibrium state.
As a person develops physical addiction or dependence on a particular drug, he/she started experiencing withdrawal symptoms in the absence of drugs. Some antidepressants or benzodiazepines medicines may increase physical dependence without making a person addict to this drug. It means that they may not impulsively search the substance, but can experience withdrawal symptoms as they stop taking these prescribed medications without consulting their doctor. It is not good to suddenly quit a drug without developing a tapered. The word “physical dependence” implies a particular craving level for a drug that is connected to withdrawal symptoms.
Physical addiction comprises of withdrawal symptoms and impulsive use of the drug to back to normal state. Cocaine may increase strong desire in drug abusers. It has physical effects instead of mental effects to stimulate your mind. The users of cocaine may enjoy particular feelings, such as a sense of achievement, high self-esteem, increased energy and suppressed appetite. It may lead to quick weight loss. In numerous situations, a person may enter in binge cycles with the excessive use of cocaine. They may suffer dangerous and serious side effects, such as damage to the respiratory system, throat, mouth, nose, delusions, paranoia and damage to the cardiovascular system.
Being the most powerful stimulant, the cocaine is extremely addictive. It affects human neurochemistry through reward pathway of the brain. Numerous people may experience its addiction even after taking it once.
The drug avoids dopamine, a neurotransmitter linked with pleasure, excitement and elevated mood, after its reabsorption. It can linger in the human brain to cause intense euphoria. Once the wear off procedure of cocaine initiates, the dopamine starts to absorb. Now the brain is really exhausted and needs help to create more dopamine. It may increase mood swings, exhaustion, depression, and numerous early withdrawal signs. At this point, the person is facing reinforcement to take another dose of cocaine to avoid these feelings.
Cocaine not only can change the release of neurotransmitters, but cocaine addiction can change the genetics of a person and increase physical addition. The drug can be responsible to activate particular genes that code for protein delta-FosB. As a result, this protein can activate the development of GluR2. It is an important constituent of glutamate receptors. These receptors are bind to the neurotransmitter glutamate. A boost in the binding capability of glutamate can increase the sensitivity of a person to the rewarding effects of cocaine, such as physical changes to reinforce a person to take the drug.